可切除非小细胞肺癌围手术期免疫治疗热点问题中国专家共识

    Chinese Expert Consensus on Key Issues in Perioperative Immunotherapy for Resectable Non-Small Cell Lung Cancer

    • 摘要: 肺癌是中国发病率及死亡率最高的恶性肿瘤,非小细胞肺癌(non-small cell lung cancer,NSCLC)是临床最常见的肺癌病理类型。手术是早期以及部分局部晚期NSCLC主要的根治性治疗手段,但即便患者接受根治性手术治疗,术后仍有肿瘤复发、转移的风险。既往数据显示,围手术期化疗为患者带来的生存获益十分有限,免疫治疗的出现为可切除NSCLC患者提供了新的治疗选择。随着围手术期免疫治疗临床应用的普及,许多免疫治疗相关的临床问题随之而来。基于此,共识专家组围绕可切除NSCLC围手术期免疫治疗热点问题进行深入讨论,最终形成本共识,以期为帮助临床医生更好地进行临床实践提供指导。

       

      Abstract: Lung cancer exhibits the highest incidence and mortality rates among malignant tumors in China, with non-small cell lung cancer (NSCLC) being the most prevalent pathological type. Surgery serves as the primary curative-intent treatment for early-stage and selected locally advanced NSCLC. However, even after radical resection, patients remain at risk of tumor recurrence and metastasis. Historical data indicate that perioperative chemotherapy offers only modest survival benefits. The advent of immunotherapy has provided a novel therapeutic option for patients with resectable NSCLC. With the increasing clinical adoption of perioperative immunotherapy, numerous immunotherapy-related clinical questions have emerged. To address this, an expert consensus panel conducted in-depth discussions on key issues surrounding perioperative immunotherapy for resectable NSCLC, culminating in the development of this consensus. The aim is to provide guidance to assist clinicians in optimizing clinical practice. (English version is available on www.jebm.cn).

       

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