Background Hydroxide ion therapy, known for its antioxidant, anti-inflammatory, and anti-apoptotic properties, has been explored as a potential therapeutic approach for cardiovascular diseases. A randomized controlled trial has shown that inhaling low-dose hydroxide ion mixtures can reduce blood pressure in middle-aged and elderly individuals with hypertension, while also decreasing plasma levels of renin-angiotensin-aldosterone system hormones and stress levels associated with hypertension. However, there was a lack of clinical evidence regarding the impact of hydroxide ions on sleep quality.
Objective This study aims to validate the effects of a small, non-contact device emitting hydroxide ions (referred to as hydroxide ions) based on magnetic energy vector light dissociation on sleep. The objective is to assess the impact of placing the device in close proximity to the bed during the night, generating hydroxide ions, on sleep quality. The study provides preliminary groundwork for subsequent randomized clinical trials.
Methods This study employed a self-controlled design, enrolling eligible participants for the administration of hydrogen ion inhalation therapy in close proximity to their beds. The assessment of participants'sleep quality changes over a 4-week period utilized the Pittsburgh Sleep Quality Index (PSQI), sleep diaries, and the Insomnia Severity Index (ISI).
Results A total of 30 voluntary participants reporting poor sleep quality were included in the study, comprising 13 males and 17 females, with ages ranging from 33 to 66 years and a mean age of (52.93 ± 9.362) years. Comparative analysis with baseline measurements revealed statistically significant improvements after inhaling hydroxide ions for 4 weeks: a reduction in the Pittsburgh Sleep Quality Index (PSQI) and Insomnia Severity Index (ISI), an increase in Nocturnal Sleep Time (TST), a shortened Sleep Onset Latency (SOL), and an enhanced Sleep Efficiency (SE) (P < 0.05).
Conclusions A preliminary exploratory clinical study reveals that the inhalation of hydroxide ions, generated through magnetic vector photolysis, exhibits the potential to enhance sleep quality without evident adverse effects.
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