Correlation between CD209-871A/G Polymorphism and Susceptibility to Tuberculosis: A Meta-Analysis

Objective To assess the correlation of CD209-871A/G polymorphism and susceptibility to tuberculosis. Methods We searched PubMed, EMBASE, Web of Science with retrieval items “DC-SIGN, CD209, ICAM-3, polymorphism, single nucleotide polymorphism, tuberculosis”, and “DC-SIGN, CD209, ICAM-3, tuberculosis, polymorphism” for China Academic Journal, Chinese BioMedical Literature Database, Wanfang Database. We collected all the publications assessing CD209-871A/G polymorphism and susceptibility to tuberculosis, excluded unrelated studies, conference abstracts, summarization and included case-control studies. The case groups were patients diagnosed with tuberculosis regardless of HIV status and the control groups were healthy people without chronic disease. Meta-analysis was performed to check the difference of genotypes including AA, GG, AG and also allele A and G between the two groups. Results A total of 3 studies were included, consisting of 726 tuberculosis patients and 744 healthy people. In the meta-analysis of total population, we did not find allele G related to susceptibility to tuberculosis OR=0.60, 95%CI（0.27,1.35）, P=0.22. However, there was a significant difference as to genotype AA OR=1.51,95%CI（1.01,2.26）,P=0.04 and allele A OR=1.28,95%CI（1.06,1.55）,P=0.01 in the two groups. Conclusions Genotype AA and allele A were related to susceptibility to tuberculosis, while -871G may be related to host immune protection to tuberculosis, which need to be confirmed by large sample of case-control studies.