Efficacy and Prognosis of Laparoscopic Radical Hysterectomy for Early Stage Cervical Cancer: A Meta-Analysis

Objective To evaluate the clinical effect on the treatment and the prognosis of laparoscopic radical hysterectomy（LRH） and pelvic lymphadenectomy（LPL） for patient with early cervical cancer. Methods The following electronic databases were searched: CBMdisc, MEDLINE, PubMed, EMBASE and Cochrane Library. All eligible literatures were assessed for quality. All data were performed by a meta-analysis. Results There were 8 literatures that met the inclusion criteria, including three prospective non-randomized controlled trials and five retrospective case-control studies, but with no RCTs. Comparing with abdominal radical hysterectomy（ARH）+ abdominal pelvic lymphadenectomy （APL）, LRH+LPL had several advantages, such as decreasing the recovery time of bowel, the blood loss during operation, postoperative hospital stays and complications of postoperation. But there was no difference in the recurrence rate and complications of intraoperation between LRH+LPL and ARH+APL. Conclusion LRH+LPL is a safe and effective alternative to conventional abdominal surgery for stage Ⅰb-Ⅱa cervical cancer. Because the quality of all the included literatures is low, the conclusion is needed to be further assessed by rigorously designed and randomized double-blind controlled trials.