Meta Analysis on Neoadjuvant Chemotherapy with Radical Surgery in Locally Advanced Cervical Cancer

Objective To evaluate the clinical efficacy of neoadjuvant chemotherapy （NACT） and radical surgery（RS） in locally advanced cervical cancer. Methods The following electronic databases were searched: CBMdisc,MEDLNE, PubMed, EMBASE, Cochrane Library. All eligible documents were assessed for quality, and extracted data were performed by a meta-analysis. Results 5 articles met the inclusion criteria, among which were four prospective randomized controlled trials and one retrospective case-control study. NACT and RS did not increase the 5-year survival rate, but increased the 5-year disease-free survival rate and decreased lymph node metastasis and parameter metastasis. Conclusion NACT and RS could be chosen to treat the locally advanced cervical cancer. It increased the 5-year disease-free survival rate and decreased lymph node metastasis and parameter metastasis. But the conclusion is needed to be further assessed by rigorously designed, randomized, double-blind, controlled trials.