Association of HLA-B Gene Polymorphism and HIV Infection and Progression in China: A Meta-Analysis

Objective To evaluate the association between gene of HLA-B and HIV infection and disease progression in Chinese population. Methods Electronic searches were conducted roundly to find the case-control studies and cross-sectional studies on the association between HLA-B gene polymorphism and HIV infection or disease course. References of relevant studies were also retrieved. The references was screened with the inclusion and exclusion criteria, and then data were extracted and methodological quality of the studies was judged. Statistical analysis was carried out with RevMan 4.2 and SAS 9.1.3. Results 11 studies were included lastly. 6 studies were about the association between gene of HLA-B and disease progression in Chinese HIV infected population, meta-analysis results revealed that the pooled OR of HLA-B?27, HLA-B?51, and HLA-B?58 were 0.49, 0.61 and 0.65 respectively, and they acted as the protective genes in the HIV/AIDS progression. HLA-B?35（pooled OR=1.87） was the risk gene in the HIV/AIDS progression. 5 studies were about the association between gene of HLA-B and HIV infection in Chinese population, meta-analysis results revealed that the pooled OR of HLA-B?37 and HLA-B?46 were 1.62 and 1.19, and they acted as the susceptible genes in HIV infection. HLA-B?39（pooled OR=0.67） was the protective gene in HIV infection. Conclusions HLA-B?27, HLA-B?51 and HLA-B?58 may act as the protective genes in HIV infected disease progression, and HLA-B?35 may act as the susceptible gene in HIV infected disease progression; HLA-B?39 may act as the protective gene in HIV infection. HLA-B?37 and HLA-B?46 may act as the susceptible genes in HIV infection.