Objective To compare the perioperative outcomes of multidisciplinary team–enhanced recovery after surgery (MDT-ERAS) versus conventional ERAS in patients undergoing robotic pancreaticoduodenectomy (RPD).

Methods A retrospective analysis was performed on 72 patients who underwent RPD at the Pancreatic Center of Guangdong Provincial People's Hospital from May 2021 to December 2024. Thirty patients received MDT-ERAS (MDT group) and 42 patients received conventional ERAS (control group). Perioperative outcomes, including time to first feeding, ambulation, flatus and defecation, length of hospital stay, hospitalization costs, pain scores, anxiety and depression scores, quality of life, and postoperative complications, were compared between the two groups.

Results  Compared with the control group, the MDT group showed significantly shorter times to first feeding, ambulation, flatus and defecation, as well as reduced length of stay, lower hospitalization costs, lower pain and anxiety/depression scores, and higher quality-of-life scores (all P < 0.05). The incidence of postoperative complications did not differ significantly between the two groups (P > 0.05).

Conclusion MDT-ERAS demonstrates significantly superior perioperative outcomes compared with conventional ERAS in patients undergoing robotic pancreaticoduodenectomy. It facilitates gastrointestinal function recovery, reduces postoperative pain, alleviates anxiety and depression, shortens hospital stay, lowers hospitalization costs, and thereby improves patients’ quality of life, while showing no significant difference in the incidence of complications.